|
KMID : 0613820100200101532
|
|
Journal of Life Science
2010 Volume.20 No. 10 p.1532 ~ p.1537
|
|
|
Comparison of Effect of Various Types of Soybeans on Mutagenicity and Growth of Human Cancer Cell Lines
|
|
Lim Sun-Young
|
|
|
Abstract
|
|
|
|
This study compared the inhibitory effects of methanol extracts from yellow and black soybeans (black soybean, Seomoktae and Seoritae) on mutagenicity using the Ames test and growth of human cancer cells (AGS human gastric adenocarcinoma, HT-29 human colon cancer, Hep 3B hepatocellular carcinoma cells). In the Ames test system using Salmonella typhimurium TA100, aflatoxin B₁ (AFB₁)-induced mutagenicity was significantly inhibited by treatments with the methanol extracts from either yellow or black soybeans in a dose dependent manner (p＜0.05). The methanol extracts from various black soybeans tended to have a greater inhibitory effect compared to those from yellow soybeans. As for N-methyl-N"-nitro-N-nitrosoguamidine (MNNG)-induced mutagenicity, the methanol extracts (5 ㎎/assay) from black soybean, Seomoktae and Seoritae showed 51%, 61% and 53% inhibitory rates, respectively, indicating that Seomoktae, a type of black soybean, had a stronger antimutagenic activity against mutagens (both AFB₁ and MNNG). Methanol extracts from black soybeans showed an inhibitory rate of greater than 50% on the growth of human cancer cells (AGS, HT-29 and Hep 3B) and the inhibition was more effective in the methanol extract from Seomoktae. Our results suggested that the methanol extracts from black soybeans showed stronger inhibitory effects on mutagenicity and growth of cancer cells than those from yellow soybean. It is concluded that intake of black soybean can be recommended for improving health.
|
|
|
KEYWORD
|
|
|
Black soybean, antimutagenicity, human cancer cells, Ames test
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|